Coming off a hideous loss at home, the Green Bay Packers are somehow favoured against the defending champion Philadelphia Eagles.
The pregame narrative: On Monday Night Football, Philly faces a Green Bay squad that's missing one of its best offensive weapons. In Sunday's action, look for the San Francisco 49ers to contend against a Los Angeles Rams squad they've already beaten this year.
Check out my top NFL Week 10 upset picks for games on Nov. 9-10.
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NFL Week 10 upset picks
Best bet: Eagles moneyline (+112)
This is the first time the Eagles have been underdogs all season. But why now?
Sure, Green Bay (5-2-1) is at home, but Philly (6-2) has the better record and is coming off a bye. The Eagles are also 3-0 vs. the Packers since 2022, with a pair of wins last season.
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Oh, and let's not forget the abomination of a performance from Green Bay's offence in Week 9. With the Carolina Panthers in town, the Packers scored just 13 points in a losing effort.
Green Bay was favoured by 13.5 points, mind you. It was by far the NFL's biggest upset of the season.
The Packers just lost tight end Tucker Kraft (knee) for the year. It'd be difficult to overstate the value of Kraft, who's third in the NFL in yards after catch (344 YAC).
None of Green Bay's wide receivers has even 100 YAC this season.
Philadelphia hasn't looked as dominant as people might expect from a defending champion, but the team has stacked wins over some impressive teams: Chiefs, Rams and Buccaneers.
It's tough to expect a proper bounce back from the Packers' offence in their first game without Kraft. The rested Eagles should take advantage.
Key stat: The Eagles rushed for 140+ yards in both games vs. Green Bay last year and won those matchups by a combined 17 points.
NFL underdog predictions
49ers moneyline (+150): San Francisco routinely has a laundry list of injuries to contend with, but a couple of key names could be back in the fold for Week 10.
- QB Brock Purdy, who has only played in two games this year, practiced all of last week and seems likely to return Sunday.
- WR Ricky Pearsall, who's averaging 80+ yards per game but hasn't played since September, "has a chance to play," according to head coach Kyle Shanahan.
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The Rams are a tough team to stop, but the Niners already have a win over them this season (26-23 in L.A. in Week 5). And that was with Mac Jones at quarterback.
With a top-10 scoring defence, the Niners won't be doormats for the Rams' loaded offence. And if Purdy/Pearsall return, expect San Francisco's offence to make some noise, too.
NFL upset picks made at 10:40 a.m. ET on 11/04/2025.
