Two of the NFC's top teams, the Philadelphia Eagles and Tampa Bay Buccaneers, are back off their bye week to take part in a 14-game slate.
The Week 10 narrative: Philadelphia has some extra rest ahead of a Monday Night Football date vs. the Green Bay Packers. Tampa Bay, meanwhile, is still far from full strength entering a big cross-conference showdown against the New England Patriots.
Check out our staff's NFL Week 10 ATS picks for predictions on every game.
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NFL Week 10 ATS picks
NorthStar Bets' Avery Perri, Jordan Horrobin, Spencer Closs, Chris Toman and Steven Psihogios offer up their NFL Week 10 ATS picks for all 14 games.
NFL odds as of 10 a.m. ET on Thursday, Nov. 6, 2025.
Thursday Night Football pick
Raiders vs. Broncos (Thursday, Nov. 6: 8:15 p.m. ET)
NorthStar Bets line: Denver -9
Closs says: Denver's offence has shown flashes, but it isn't good enough to warrant this large spread. The Broncos have covered this number in just two of seven wins this season against the two worst defensive teams in football (Bengals, Cowboys). Additionally, Brock Bowers is healthy for the Raiders. With its star tight end, Las Vegas is 3-2 against this spread.
Staff picks: Perri (LV) | Horrobin (LV) | Closs (LV) | Toman (DEN) | Psihogios ()
NFL ATS picks: The early Sunday slate
Falcons vs. Colts (Sunday, Nov. 9:30 a.m. ET)
NorthStar Bets line: Indianapolis -6.5
Closs says: Atlanta looks like a different team when healthy. Michael Penix Jr. and Drake London returned last week to connect for three TDs in a 24-23 loss to the Patriots. With both skill players in the lineup, Atlanta is 5-2 against this spread. Indianapolis is coming off a seven-point loss to the Steelers and could be without top receiver Michael Pittman Jr. and starting cornerback Kenny Moore. A lot is working in the Falcons' favour in Week 10.
Staff picks: Perri (IND) | Horrobin (ATL) | Closs (ATL) | Toman (ATL) | Psihogios ()
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Ravens vs. Vikings (Sunday, Nov. 9: 1 p.m. ET)
NorthStar Bets line: Baltimore -4.5
Perri says: Every game feels like a must-win for the Ravens, who sit at 3-5 after a dreadful start to the season. But with Lamar Jackson back in the fold, I can see them potentially running the table. Jackson threw for four touchdowns in his return last week and owns a stellar 24-5 record against NFC teams. Baltimore's defence has also sneakily improved, allowing just 13.0 PPG in its last three games.
Staff picks: Perri (BAL) | Horrobin (MIN) | Closs (BAL) | Toman (MIN) | Psihogios ()
Bills vs. Dolphins (Sunday, Nov. 9: 1 p.m. ET)
NorthStar Bets line: Buffalo -9.5
Toman says: Buffalo beat Miami by 10 in Week 3 but failed to cover the lofty 12-point spread. The Bills are recharged, and the Dolphins have been held under 10 points in two of their last three weeks. Coming out of its bye, Buffalo has a 31-point win and an underdog victory over the Chiefs. Josh Allen has obliterated the Dolphins throughout his career — expect more of the same this Sunday.
Staff picks: Perri (BUF) | Horrobin (BUF) | Closs (BUF) | Toman (BUF) | Psihogios ()
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Browns vs. Jets (Sunday, Nov. 9: 1 p.m. ET)
NorthStar Bets line: Cleveland -2
Perri says: I'll happily back Cleveland in this battle of destitute franchises. New York is 1-7 and just traded away its best two defensive players, Sauce Gardner and Quinnen Williams, at the deadline. The Browns' defence ranks top-five in EPA per play and yards allowed per game and should stifle anything Justin Fields (or Tyrod Taylor) has to offer.
Staff picks: Perri (CLE) | Horrobin (CLE) | Closs (CLE) | Toman (CLE) | Psihogios ()
Jaguars vs. Texans (Sunday, Nov. 9: 1 p.m. ET)
NorthStar Bets line: Jacksonville -1.5
Closs says: The Texans will be without C.J. Stroud, but I don't think that hurts them much. Davis Mills should be a fine replacement, while the defence allows the fewest points per game (15.1). That alone makes it difficult for opponents to pull away. Jacksonville is 5-3 but hasn't won by more than a possession since Week 1. This is likely going to be an ugly game, which has me siding with the defensively sound Texans at home.
Staff picks: Perri (JAX) | Horrobin (JAX) | Closs (HOU) | Toman (JAX) | Psihogios ()
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Patriots vs. Buccaneers (Sunday, Nov. 9: 1 p.m. ET)
NorthStar Bets line: Tampa Bay -2.5
Perri says: Tampa Bay is fresh off a much-needed bye week, but is still likely without Chris Godwin and Bucky Irving (with Mike Evans on injured reserve). That has me content backing New England, which is among the league's hottest teams. The Pats are averaging 29.5 PPG during their six-game winning streak, while getting MVP-calibre play out of sophomore Drake Maye.
Staff picks: Perri (NE) | Horrobin (NE) | Closs (NE) | Toman (TB) | Psihogios ()
Saints vs. Panthers (Sunday, Nov. 9: 1 p.m. ET)
NorthStar Bets line: Carolina -5.5
Horrobin says: The Tyler Shough Era got off to a predictably disastrous start last week in New Orleans’ 34-10 loss in L.A. The Saints are back on the road this Sunday and should be in for another loss against the resurgent Panthers. Carolina is 6-3 ATS and just earned the NFL’s biggest upset win of the year last Sunday (beating Green Bay as a 13.5-point underdog). New Orleans has lost its past four games by a combined 62 points.
Staff picks: Perri (CAR) | Horrobin (CAR) | Closs (CAR) | Toman (CAR) | Psihogios ()
Giants vs. Bears (Sunday, Nov. 9: 1 p.m. ET)
NorthStar Bets line: Chicago -4.5
Toman says: New York is down multiple playmakers on the road and has lost five games by double digits. The Bears have been competitive in nearly every game and have reeled off wins in five of their last six. Back home after back-to-back road games, they should handle the banged-up Giants.
Staff picks: Perri (CHI) | Horrobin (CHI) | Closs (CHI) | Toman (CHI) | Psihogios ()
NFL 4 p.m. slate
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Cardinals vs. Seahawks (Sunday, Nov. 9: 4:05 p.m. ET)
NorthStar Bets line: Seattle -6.5
Perri says: Jacoby Brissett is 3-0 ATS as a starter, and Arizona already covered this number against Seattle at home in Week 4. But I think the Seahawks' No. 5 scoring defence, which has held seven of eight opponents to 20 or fewer points, can put an end to Brissett's impressive run. Seattle is a league-best 6-2 ATS and has covered this number in three straight weeks.
Staff picks: Perri (SEA) | Horrobin (SEA) | Closs (ARI) | Toman (ARI) | Psihogios ()
Lions vs. Commanders (Sunday, Nov. 9: 4:25 p.m. ET)
NorthStar Bets line: Detroit -8
Toman says: All five of the Lions’ wins have been by eight-plus points. Against a Commanders team that’s without QB Jayden Daniels and has lost three straight by double digits, I anticipate another blowout victory for Detroit. The Lions should be hungry following an upset loss in Week 9.
Staff picks: Perri (DET) | Horrobin (DET) | Closs (DET) | Toman (DET) | Psihogios ()
Rams vs. 49ers (Sunday, Oct. 19: 4:25 p.m. ET)
NorthStar Bets line: Los Angeles -4.5
Horrobin says: Brock Purdy has a legitimate shot at returning this week, and there’s an outside chance Ricky Pearsall is back, too. But even if it’s the Mac Jones show, I know he gives the Niners a chance to win because he’s already beaten the Rams this season (throwing for 342 yards in a 26-23 road victory). San Francisco has the 10th-ranked scoring defence and should be able to hang regardless of who’s under centre.
Staff picks: Perri (SF) | Horrobin (SF) | Closs (SF) | Toman (SF) | Psihogios ()
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Sunday and Monday Night NFL Week 10 ATS picks
Steelers vs. Chargers (Sunday, Nov. 9: 8:20 p.m. ET)
NorthStar Bets line: Los Angeles -3
Perri says: I can't make much sense of Pittsburgh's season so far. The Steelers just shut down the NFL's best offence (Colts) after giving up 30-plus points in back-to-back weeks to the Packers and Bengals. I'm hoping Mike Tomlin's group turned the corner, and expect T.J. Watt to lead the pass rush against a Chargers offensive line missing Joe Alt and several other key pieces.
Staff picks: Perri (PIT) | Horrobin (PIT) | Closs (PIT) | Toman (PIT) | Psihogios ()
Eagles vs. Packers (Monday, Nov. 10: 8:15 p.m. ET)
NorthStar Bets line: Green Bay -2.5
Horrobin says: Philadelphia hasn’t won many of its games in convincing fashion, but this team doesn’t deserve to be an underdog in Green Bay. The Eagles, who beat the Packers twice last year, are 6-2 and coming off a bye. Green Bay lost as a 13.5-point favourite last week and will have to figure out its offence without arguably its most important playmaker, Tucker Kraft.
Staff picks: Perri (GB) | Horrobin (PHI) | Closs (PHI) | Toman (PHI) | Psihogios ()
NFL ATS picks: Week 9 + season records: Closs: 7-7-0 (68-67-0) | Psihogios: 9-5-0 (66-69-0) | Toman: 8-6-0 (66-69-0) | Perri: 7-7-0 (66-69-0) | Horrobin: 5-9-0 (61-74-0)
