The NFL is entering its home stretch, with no more bye weeks and just four games to play before the postseason.
Week 15 at a glance: The Kansas City Chiefs' dynasty is on its last legs, as Patrick Mahomes and Co. need a win to stay alive and defend their AFC title. Elsewhere, two NFC juggernauts, the Detroit Lions and Los Angeles Rams, do battle at SoFi Stadium.
Check out our NFL Week 15 betting guide for staff picks and predictions on the 16-game slate.
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NFL Week 15 betting guide: predictions
ATS picks: Get ATS predictions from our five staff writers on every game of the week.
Prop bets: Philip Rivers is on the cusp of an improbable return to the NFL. He's one of three Sunday targets for Week 15, alongside this year's No. 1 pick, Cam Ward.
Best bets: Our staff has two ATS picks, one moneyline prediction and a player prop on MVP favourite Matthew Stafford.
Upset picks: Joe Burrow and the Bengals' offence are firing on all cylinders. That makes Cincinnati an enticing divisional underdog against a clearly hobbled Lamar Jackson.
Thursday Night Football SGP: Mike Evans is slated to return from injury, and he factors into this +340 wager also featuring Bijan Robinson and Rachaad White.
NFL injury report: Who's in? Who's out? Our NFL injury report, powered by RotoWire, provides the latest status updates for players around the league.
NFL Week 15 betting notes
- The Chiefs are laying 5.5 points in a must-win game. From 2018-24, KC went 95-23 (.805) straight up as favourites, per Team Rankings. This year, the team is just 5-6 (.455).
- Jared Goff, Dan Campbell, and the Lions head west with a rest advantage. As a duo, Goff and Campbell are 17-3 ATS as underdogs above a field goal, per Action Network.
- Welcome back, Phillip Rivers! It's looking like the Indianapolis Colts will be starting a grandfather under centre this week. The only other time that has happened was when Brett Favre suited up in 2010 for the Minnesota Vikings.
-> Don't miss out — bet on NFL Week 15 here!
-> Don't miss out — bet on NFL Week 15 here!
- There are three teams favoured by double digits on Sunday, including the Seattle Seahawks (-14), who look to send Rivers and the Colts to the glue factory. The San Francisco 49ers (-12.5) and Jacksonville Jaguars (-13) also hold that distinction.
- Mike Tomlin and the Pittsburgh Steelers have a fantastic ATS record on Monday Night Football. They're 11-1 SU at home when closing out the week, but they'll likely be without star pass rusher T.J. Watt, who was hospitalized with lung discomfort on Thursday.
- Pittsburgh will host the Miami Dolphins in sub-zero temperatures. Tua Tagovailoa has struggled in the cold, going 0-5 SU and losing by an average of 19.2 PPG in sub-40-degree-Fahrenheit weather. It's projected to be 20 Fahrenheit (-6 °C) on Monday.
Biggest spreads: Colts vs. Seahawks (-14); Jets vs. Jagauars (-13); Titans vs. 49ers (-12.5)
Highest totals: Lions vs. Rams (55); Ravens vs. Bengals (51.5); Bills vs. Patriots (49.5)
NFL Week 15 matchups
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-> Bet on Gibbs and Williams at NorthStar Bets!
Thursday Night Football (Dec. 11)
- Falcons vs. Buccaneers (8:15 p.m. ET)
Sunday, Dec. 14: 1 p.m. ET slate
- Cardinals vs. Texans
- Ravens vs. Bengals
- Bills vs. Patriots
- Browns vs. Bears
- Raiders vs. Eagles
- Chargers vs. Chiefs
- Jets vs. Jaguars
- Commanders vs. Giants
Sunday, Dec. 14: 4 p.m. ET slate
- Titans vs. 49ers
- Colts vs. Seahawks
- Packers vs. Broncos
- Lions vs. Rams
Sunday Night Football
- Vikings vs. Cowboys (8:20 p.m. ET)
Monday Night Football (Dec. 15)
- Dolphins vs. Steelers (8:15 p.m. ET)
