Saquon Barkley looks to score in a fourth straight game when the Philadelphia Eagles take on the Buffalo Bills.
The pregame narrative: Earlier in the afternoon slate, bet on Jaxon Smith-Njigba to find the end zone as the Seattle Seahawks look to do their part in clinching the NFC West with a win over the Carolina Panthers.
Check out my top NFL Week 17 TD picks.
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NFL Week 17 TD picks
Best bet: Barkley to score (+100)
After getting washed-up allegations, Barkley has come alive in the latter part of the season:
- Week 14: 132 rushing yards, one touchdown
- Week 15: 78 rushing yards, one touchdown
- Week 16: 122 rushing yards, one touchdown
He's been performing when it matters most to help secure the Eagles a playoff spot.
And now he has a great matchup to find the end zone again.
-> Go to full Eagles vs. Bills prop markets
The Bills allow the fourth-most rushing yards per game (144.3). They've also conceded a league-high 18 touchdowns to running backs this season.
It's no secret Philly will try its hand with the run game, given its personnel.
Barkley should see the rock whenever the Eagles make a trip to the red zone. He has 22 rushes inside 10 yards this season, but it's only equated to three scores.
Chances are that changes, and Barkley is running hot right now.
Key stat: The Bills have the second-worst rush EPA in the NFL (0.080), per rbsdm.com
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NFL Week 17 touchdown bets
Smith-Njigba to score (+100): JSN is the WR1 heading into the final weeks of the NFL season.
- 104 receptions
- 10 TDs
- 1,637 yards
In last week's thrilling win over the Los Angeles Rams, Smith-Njigba grabbed the game-winning touchdown in overtime. He's now scored five TDs in the past five games.
-> Bet on NFL Sunday prop markets
His 16 red zone targets also rank fourth in the NFL, showing his growing connection with Sam Darnold.
The Panthers provide a decent matchup, ranking right in the middle of the pack for yards allowed per game (209.6)
Even a decent matchup is too little to stop JSN. He has every right to exploit this defence for another big week.
NFL TD picks made at 12:20 p.m. ET on Dec. 24, 2025.
