Eagles vs. Bills Week 17 SGP predictions: Bet on Cook to score, Buffalo to win at +310

Bet on James Cook and the Buffalo Bills on Sunday. Photo by Robert F. Bukaty/AP.
Bet on James Cook and the Buffalo Bills on Sunday. Photo by Robert F. Bukaty/AP.

The Philadelphia Eagles and Buffalo Bills collide in a heavyweight clash on Sunday afternoon.

The pregame narrative: Philadelphia and Buffalo are Super Bowl contenders, but neither has really looked the part this season. Both squads can earn a statement win before the last week of the season.

Check out my Eagles vs. Bills SGP predictions, featuring James Cook.

northstar bullet point BET FINDER: Search & Bet!

-> Join NorthStar Bets to start betting on the NFL

Eagles vs. Bills predictions

SGP: Bills ML | Cook to score a TD | Over 40.5 points (+310)

Bills ML (-124): I'm not buying that the Eagles are back.

Sure, Philadelphia has won consecutive games since an embarrassing loss to the Los Angeles Chargers on Monday Night Football. Those wins, however, require significant context:

  • The Eagles shut out the lowly Las Vegas Raiders, 31-0, who were playing with backup QB Kenny Pickett under centre.
  • Buffalo's most recent win, a 29-18 victory over the Washington Commanders, came against the QB duo of Marcus Mariota and Josh Johnson.

It's worth noting, too, that the Commanders led at halftime of the Week 16 contest (10-7).

Buffalo wasn't at its best in a narrow win over the Cleveland Browns last week, but it did overcome a 21-0 deficit against the New England Patriots just a week before.

The Bills still have an outside shot at winning the division, too, which should ensure they bring a competitive effort to this contest.

Other SGP picks

Cook to score a TD (-105): Josh Allen suffered a foot injury in Week 16, and that's certainly worth highlighting here.

The Bills quarterback finished with just 17 rushing yards against the Browns, his lowest total since Week 8.

Allen was limited at practice at points during the week, and my guess is Buffalo will limit his rushing opportunities.

That could mean more looks to Cook at the goal line.

Cook is heating up at the right time for Buffalo, too, as the running back has five touchdowns across his last two games.

What makes Cook an exciting pick in this market is his ability to break one from anywhere on the field. He's tied for second in the NFL with four rushes of 40-plus yards this year.

Over 40.5 points (-180): Lastly, I expect this game to usurp a manageable point total.

Both teams are capable of scoring. The Bills are third in points per game (28.9), while the Eagles are tied for 16th (23.3).

  • Buffalo has cashed this total in eight of its last nine games.
  • Philadelphia has topped this number in three of its last five outings.

Buffalo's combination of elite offence and beatable defence makes it one of the best overs squads in the league. The Bills have scored and allowed 20-plus points in over half their games this season (eight).

Eagles vs. Bills predictions made at 2:04 p.m. on Dec. 27, 2025.

NorthStar Bets Responsible Gaming Policy: Click Here
NorthStar Bets Editorial Standards and Principals: Click Here