Lionel Messi and Inter Miami host the Vancouver Whitecaps in the MLS Cup on Saturday.
The pre-match narrative: The Herons are favoured to lift the trophy after bulldozing through the playoffs with Messi leading the charge. The Whitecaps needed a pair of shootout victories to get here, but they shouldn't be overlooked with a resurgent Thomas Muller at the helm.
Check out our 2025 MLS Cup odds and betting preview
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MLS Cup odds 2025
| Market | Odds |
| Inter Miami | -139 |
| Draw | +350 |
| Vancouver Whitecaps | +325 |
| Inter Miami to lift trophy | -250 |
| Vancouver Whitecaps to lift trophy | +195 |
| Both teams to score — yes | -265 |
| Both teams to score — no | +180 |
| Over 3.5 goals | -108 |
| Under 3.5 goals | -115 |
MLS Cup odds as of 2:30 p.m. ET on Dec. 2, 2025.
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Inter Miami vs. Vancouver Whitecaps betting preview
The favourites: Inter Miami (-250)
MLS Cups were promised when Messi joined in 2023, and now the Argentine has a chance to deliver.
Inter Miami went 19-8-7 this season, one point back of first place in the Eastern Conference. The club carried that dominance into the playoffs:
- Round 1: Beat Nashville in best-of-three series (8-3 aggregate score)
- Conference semis: Beat FC Cincinnati (4-0)
- Conference finals: Beat New York City FC (5-1)
Messi leads the way with six goals and five assists in five games, while the defence has held opponents to just one goal in the past three games.
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The underdogs: Vancouver Whitecaps (+325)
Vancouver's road to the final was a tad rockier.
The Whitecaps beat FC Dallas in penalties to sweep the Round 1 series and then needed penalties again to topple LAFC in the conference semis.
They took down San Diego FC 3-1 in the conference finals, though, and head into this match with just one loss in their last 13 games.
Muller, Germany's top goalscorer and assist provider in the Champions League, has had an immediate impact.
The forward has eight goals and four assists in 11 starts for Vancouver.
Lionel Messi MLS Cup goal odds
| Player to score | Odds |
| Lionel Messi (MIA) | -175 |
| Luis Suarez (MIA) | +135 |
| Tadeo Allende (MIA) | +155 |
| Thomas Muller (VAN) | +160 |
| Brian White (VAN) | +170 |
-> Bet on Lionel Messi to score!
Messi holds the shortest odds of any player to score after his recent hot streak.
Two of his teammates — Luis Suarez and Tadeo Allende — are next on the board ahead of Muller and fellow Whitecap Brian White.
