The San Francisco 49ers host the Carolina Panthers on Monday Night Football in a game surprisingly filled with playoff implications.
The pregame narrative: Many expected San Francisco to be in the playoff hunt. Carolina? Not so much. Both squads are vying for a crucial win to keep pace in a loaded NFC as we near the stretch run.
Check out my +255 same-game parlay Panthers vs. 49ers predictions for Nov. 24, featuring George Kittle.
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Panthers vs. 49ers predictions
SGP: 49ers -2.5 | Kittle over 55.5 receiving yards | Over 45.5 points (+255)
49ers -2.5 (-286): Carolina enters this contest just one game back of San Francisco for first in the final playoff spot in the NFC.
But San Francisco is a significant 7-point favourite.
This line suggests that Carolina’s record is misleading. I agree, to an extent.
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I’m not smashing San Francisco to cover by seven, but I’m confident it’ll come through on this line.
The first thing that jumps out to me in this game is Carolina’s stark home-road splits:
- 3-2 at home, 20.6 points per game, 21.6 points allowed per game.
- 3-3 on the road, 17.3 points per game, 23.5 points allowed per game.
The Panthers have been notably better at home, especially considering that one of their losses was a 40-9 defeat to the Buffalo Bills with Andy Dalton at the helm.
It’s been a different story away from Bank of America Stadium. Two of the team’s three losses have come by 16-plus points as a visitor.
San Francisco looked great with Brock Purdy back in its 41-22 win over the Arizona Cardinals in Week 11. I expect another strong performance from the offence.
Monday Night Football SGP picks
Kittle over 55.5 receiving yards (-114): One thing is abundantly clear: Purdy loves him some Kittle.
The tight end’s production spikes significantly with Purdy under centre. Here are his numbers since Purdy joined the Niners:
- With Purdy: 40 games, 66.3 receiving yards per game, 26 touchdowns
- Without Purdy: 12 games, 40.8 receiving yards per game, four touchdowns
The quarterback wasted no time peppering his main man in his Week 11 return.
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Kittle caught all six of his targets for 67 yards and two touchdowns against Arizona.
The Panthers are struggling to limit opposing tight ends, surrendering the sixth-most receiving yards per game to the position (65.3).
Over 45.5 points (-180): Lastly, I’m expecting both teams to score a fair share of points.
The 49ers don’t have the pieces on defence to shut down opposing teams. They have significant injuries at every level of the unit and can only do so much to mask the losses.
San Francisco has allowed 28.5 points per game across its last four outings. Naturally, it's cashed this over in three of those games.
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Carolina, meanwhile, is coming off a 30-point performance against the Atlanta Falcons. It also has a path to moving the ball on offence.
The Niners are 25th in opponent yards per pass (6.9).
Bryce Young should be able to move the ball enough to get this over the total.
Panthers vs. 49ers predictions made at 12:36 p.m. ET on Nov. 23, 2025.
