There are some big spreads on the board during this weekend's NFL slate.
The Week 12 narrative: The Seattle Seahawks, Detroit Lions and Baltimore Ravens are all favoured by double digits. Our staff has split opinions on how those games will go, but are largely aligned on the Cleveland Browns and San Francisco 49ers.
Check out our staff's NFL Week 12 ATS picks for predictions on every game.
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NFL Week 12 ATS picks
NorthStar Bets' Avery Perri, Jordan Horrobin, Spencer Closs, Chris Toman and Steven Psihogios offer up their NFL Week 12 ATS picks for all 15 games.
NFL odds as of 10 a.m. ET on Thursday, Nov. 20, 2025.
Thursday Night Football pick
Bills vs. Texans (Thursday, Nov. 20: 8:15 p.m. ET)
NorthStar Bets line: Buffalo -6
Closs says: Buffalo isn't the same team on the road. It lost as the away favourite in Week 6 against the Falcons and again in Week 10 against the Dolphins. The Texans have the NFL's best defence, allowing the fewest yards and points per game. The Bills should struggle to score, making this high spread less attainable. I'll side with Houston at home.
Staff picks: Perri (BUF) | Horrobin (HOU) | Closs (HOU) | Toman (BUF) | Psihogios (BUF)
NFL ATS picks: The early Sunday slate
Colts vs. Chiefs (Sunday, Nov. 23: 1:00 p.m. ET)
NorthStar Bets line: Kansas City -3.5
Horrobin says: Coming off a bye, Indianapolis should be able to at least keep this close. Both of the Colts’ losses this season have come in one-score games, and they’re top 10 in EPA on both sides of the ball since Week 5 (according to RBSDM.com). The Chiefs have lost back-to-back games outright as favourites.
Staff picks: Perri (KC) | Horrobin (IND) | Closs (KC) | Toman (IND) | Psihogios (IND)
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Vikings vs. Packers (Sunday, Nov. 23: 1 p.m. ET)
NorthStar Bets line: Green Bay -6.5
Horrobin says: Green Bay lost close in both matchups against Minnesota last season, but that was with Sam Darnold at the helm for the Vikes. Now it’s work-in-progress QB J.J. McCarthy under centre, and he doesn’t scare me one bit. McCarthy has seven interceptions and a 50.8% completion rate over his past four games, and three of those matchups were at home. Green Bay has covered this number in three of five at Lambeau.
Staff picks: Perri (GB) | Horrobin (GB) | Closs (MIN) | Toman (MIN) | Psihogios (MIN)
Patriots vs. Bengals (Sunday, Nov. 23: 1 p.m. ET)
NorthStar Bets line: New England -7
Horrobin says: Joe Burrow might play on Sunday, but no matter what, he won’t be suiting up on defence. And that’s where Cincinnati needs help most, as the Bengals rank dead last in points and yards allowed. New England is on an eight-game winning streak and is 6-2 ATS in that span. Drake Maye is the NFL’s passing leader, and the Pats’ defence is top 10 in both scoring and total yardage.
Staff picks: Perri (CIN) | Horrobin (NE) | Closs (CIN) | Toman (NE) | Psihogios (NE)
Giants vs. Lions (Sunday, Nov. 23: 1 p.m. ET)
NorthStar Bets line: Detroit -11
Perri says: Detroit has won and covered 13 straight games following a loss. That includes three instances this year, which it won by an average of 22.0 points. The Lions are also back home, where they've been decimating teams. I can't picture the shorthanded Giants putting up any sort of fight against Dan Campbell's squad.
Staff picks: Perri (DET) | Horrobin (NYG) | Closs (DET) | Toman (DET) | Psihogios (DET)
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Jets vs. Ravens (Sunday, Nov. 23: 1 p.m. ET)
NorthStar Bets line: Baltimore -13.5
Closs says: The Ravens should be able to run all over the Jets. New York's defence gives up 130.9 rushing yards per game, while Baltimore has averaged 168 rushing yards in the two games since Lamar Jackson returned. That was also against two of the toughest defences in the NFL (Browns, Vikings). The Ravens should have a lot of possession time in this game while running up the score.
Staff picks: Perri (BAL) | Horrobin (BAL) | Closs (BAL) | Toman (NYJ) | Psihogios (NYJ)
Steelers vs. Bears (Sunday, Nov. 23: 1 p.m. ET)
NorthStar Bets line: Chicago -3
Horrobin says: Stylistically, I like this matchup for Chicago. The Bears have the second-most rushing yards this season and should be able to pound the rock against the Steelers, whose defence ranks 30th in EPA per rush since Week 5. Chicago is 7-1 SU and 6-2 ATS in its past eight games, while Pittsburgh is 1-3 ATS on the road.
Staff picks: Perri (PIT) | Horrobin (CHI) | Closs (CHI) | Toman (CHI) | Psihogios (PIT)
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Serahawks vs. Titans (Sunday, Nov. 23: 1 p.m. ET)
NorthStar Bets line: Seattle -13.5
Perri says: I won't put much stock into Seattle's loss last week. The Seahawks out-gained the Rams by 165 yards and had 15 more minutes of possession but were sunk by Sam Darnold's four interceptions. Tennessee is nothing like L.A., sitting at 1-9 with the league's worst point differential (-130). Seattle has the second-best point differential (+101) and should rebound emphatically.
Staff picks: Perri (SEA) | Horrobin (TEN) | Closs (TEN) | Toman (SEA) | Psihogios (SEA)
NFL 4 p.m. slate
Browns vs. Raiders (Sunday, Nov. 23: 4:05 p.m. ET)
NorthStar Bets line: Raiders -4
Horrobin says: I don’t expect Shedeur Sanders to be great in his first NFL start, but I do expect Browns head coach Kevin Stefanski to make Sanders’ life as easy as possible. The main reason I like Cleveland is its No. 2-ranked total defence, which is easily the best unit for either side. The Raiders are 3-6-1 ATS overall and have only surpassed 20 points in one of their past six games.
Staff picks: Perri (CLE) | Horrobin (CLE) | Closs (CLE) | Toman (CLE) | Psihogios (CLE)
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Jaguars vs. Cardinals (Sunday, Nov. 23: 4:05 p.m. ET)
NorthStar Bets line: Jaguars -3
Perri says: Jacoby Brissett has played well for Arizona in Kyler Murray's absence, posting a 10:3 TD-to-INT ratio while averaging 314 passing yards per game. He's 3-2 ATS as a starter and should be able to move the ball against Jacksonville's defence. The Jags just swarmed a depleted Chargers o-line, but they had allowed 100 points in the three games before that.
Staff picks: Perri (ARI) | Horrobin (ARI) | Closs (ARI) | Toman (JAX) | Psihogios (JAX)
Falcons vs. Saints (Sunday, Nov. 23: 4:25 p.m. ET)
NorthStar Bets line: New Orleans -1.5
Perri says: Atlanta has lost three straight heartbreakers and is now down Michael Penix Jr. (ACL). But I still don't think that warrants New Orleans being favoured in any capacity. The Saints are 2-8 and have the fourth-worst point differential (-95) in football. The Saints' defence ranks 26th in pass rush win rate, so Kirk Cousins should have enough time to operate.
Staff picks: Perri (ATL) | Horrobin (ATL) | Closs (NO) | Toman (ATL) | Psihogios (NO)
Eagles vs. Cowboys (Sunday, Nov. 16: 4:25 p.m. ET)
NorthStar Bets line: Philadelphia -3.5
Horrobin says: The Eagles have been a frustrating watch for much of the season, but they've covered in four straight and are 7-3 ATS on the year. They covered this number against the Cowboys earlier in the season and won last year's matchups by a combined 62 points. Dallas has the type of defence (read: terrible) that might actually kick Philly's offence into gear.
Staff picks: Perri (DAL) | Horrobin (PHI) | Closs (DAL) | Toman (DAL) | Psihogios (DAL)
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Sunday and Monday Night NFL Week 12 ATS picks
Buccaneers vs. Rams (Sunday, Nov. 23: 8:20 p.m. ET)
NorthStar Bets line: Los Angeles -6.5
Closs says: The Rams are serious contenders. They rank top six in scoring on both sides of the ball and are on a five-game win streak. During that time, they've held opponents to 13.0 points per game while scoring 29.8. Tampa Bay has lost back-to-back games and doesn't have the defence to keep pace in this matchup.
Staff picks: Perri (LAR) | Horrobin (LAR) | Closs (LAR) | Toman (LAR) | Psihogios (LAR)
Panthers vs. 49ers (Monday, Nov. 24: 8:15 p.m. ET)
NorthStar Bets line: San Francisco -7
Perri says: It only took 12 weeks, but the 49ers' offence is finally healthy (sans Brandon Aiyuk, who has yet to debut). Brocky Purdy threw three touchdowns in a 41-22 win over the Cardinals last week, and I expect more fireworks against a Panthers defence ranking 24th in EPA per play.
Staff picks: Perri (SF) | Horrobin (SF) | Closs (SF) | Toman (SF) | Psihogios (SF)
NFL ATS picks: Week 11 + season records: Closs: 3-9-3 (78-83-3) | Psihogios: 7-5-3 (81-80-3) | Toman: 7-5-3 (76-85-3) | Perri: 6-6-3 (77-84-3) | Horrobin: 7-5-3 (74-87-3)
